USMLE Step 1 Question of the Week #13

A 26-year-old man presents to ophthalmologist for complain of progressive loss of vision in his right eye for last six months. He has visited multiple doctors till date, but there is no improvement. There is no history of pain or redness in eyes. He often experiences fatigue for last one year. His detailed medical history reveals that he has suffered from fractures of different long bones two times; both the fractures were associated with minor injury. His detailed ophthalmologic evaluation suggests diagnosis of optic atrophy on right side. His recent complete blood counts revealed that his blood hemoglobin level was 9.2 g/dL (5.71 mmol/L). Considering a specific condition as a differential diagnosis, the ophthalmologist orders radiogram of his spine, which confirms the diagnosis. The radiogram is shown below:

Which of the following mechanisms best explains pathophysiology of the condition the man is suffering from?

A. Abnormal accumulation of mucopolysaccharides in chondrocytes

B. Decreased synthetic activity of osteoblasts

C. Primary oversecretion of parathyroid hormone

D. Defective acidification of osteoclast resorption pit

E. Defective assembly of collagen polypeptides.


QID #1838


USMLE Step 1 Question of the Week #12

A male newborn, delivered at full term, has abnormal facies and is suspected to have a chromosomal anomaly. Histological examination of his umbilical cord shows following findings:

Which of the following chromosomal anomalies is most commonly associated with above findings in umbilical cord?


A. Down syndrome

B. Edward syndrome

C. Klinefelter syndrome

D. Patau syndrome

E. Turner syndrome

QID #1023

USMLE Step 1 Question of the Week #12

A 60-year-old man presents to ophthalmologist with history of progressive decline in vision in his right eye for last six months. After complete ocular examination, the ophthalmologist confirms diagnosis of cataract in his right eye. Additionally, he also notes a congenital defect in his iris on both sides. Image of the iris defect in his left eye is shown below.

Failure of closure of choroid fissure during which week of gestation results in above defect?

A. Week 6

B. Week 7

C. Week 8

D. Week 10

E. Week 11

QID #1017

USMLE Step 1 Question of the Week #11

A 27-year-old woman comes to the clinic and complains of difficulty with sexual intercourse. History taking proves to be difficult as she is very unwilling to discuss her perceived reasons for the difficulties. She claims that she is in a new relationship and met her current partner two weeks ago. In addition, she reports that she has never had any problem in initiating and maintaining sexual activity in her past relationships and that the lack of desire has also never been a problem. Apart from this, she states that she was sexually abused when she was a child but does not want to talk about it at all. Her chief complaint is that she has pain and stiffness during intercourse and that this has started only with this relationship. On examination, the physiciannotices some resistance during vaginal examination and the patient also complains of pain when he attempts this examination. What is the most likely diagnosis?

A. Dyspareunia

B. Vaginismus

C. Hypoactive sexual disorder

D. Sexual aversion disorder

E. Female sexual arousal disorder

QID #809

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