USMLE Step 1 Question of the Week #7

A 24-year-old woman presents to physician with complain of cough and wheezing for three days. She mentions that she has been experiencing similar episodes for last two years and the episodes are more frequent in winter months as compared to other seasons. Cough is usually non-productive or with scanty expectoration. Use of inhaled salbutamol, as prescribed by his physician one year back, quickly relieves her symptoms. Her mother is a known case of allergic rhinitis. On physical examination, her temperature is 98.4ºF (36.9ºC), pulse rate is 84/minute, blood pressure is 128/80 mm Hg, and respirations are 22/minute. Auscultation of her lungs shows presence of end-expiratory wheezing bilaterally. Her peak expiratory flow rate is 70% of expected for her age, which improves to 90% of expected for her age after use of inhaled salbutamol. The physician suggests her a few laboratory investigations for diagnostic evaluation. Her differential white blood cell count show 9% of eosinophils and microscopic examination of her sputum shows numerous eosinophils and crystals.

Which of the following proteins is most likely to be present in the crystals?

A. Spondin-1

B. Protein

C. E-selectin

D. Galectin-10

E. Laminin

QID # 2311

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